Protease

Proteins & Amino AcidsCAS: 9014-01-1

This is what the ingredient is.

Protease (or peptidase) is an enzyme that breaks down proteins into peptides and amino acids.

Here is why it shows up on the label.

Used in meat tenderization, cheese making, bread improvement, and protein hydrolysis. Papain and bromelain are natural proteases.

Here is what food agencies say.

The FDA lists it as Generally Recognized as Safe. European food agencies allow it. Used as processing aid in various food applications.

Here is what research has found.

Natural digestive enzyme. Plant sources (papaya, pineapple) traditionally used for tenderizing. an FAO/WHO expert committee reviewed safety.

Here are a few things worth knowing.

Generally safe in food. Papain may cause allergic reactions in latex-sensitive individuals.

Sources

  • FDA CFR 21
  • EFSA Scientific Opinion
  • JECFA Monograph

How to read this page

We publish plain facts about this ingredient so a label is easier to read. This is not medical advice, and it is not a recommendation to buy, avoid, or use anything. For a personal health question, talk with a clinician who knows your history.

v1.0Updated 9/12/2026