Microcrystalline Cellulose

Thickeners & StabilizersCAS: 9004-34-6

This is what the ingredient is.

Microcrystalline cellulose (MCC) is purified, partially depolymerized cellulose derived from wood pulp or cotton.

Here is why it shows up on the label.

Used as anticaking agent, bulking agent, and tablet binder. Provides texture without calories. Common in supplements.

Here is what food agencies say.

The FDA lists it as Generally Recognized as Safe. European food agencies allow it (E460). It is permitted in many countries worldwide.

Here is what research has found.

Inert and not digested or absorbed. an FAO/WHO expert committee confirms safety. Used in pharmaceuticals for decades.

Here are a few things worth knowing.

Generally safe. Passes through GI tract as fiber. No nutritional value. Some prefer to avoid in supplements.

Sources

  • FDA CFR 21
  • EFSA Panel on Food Additives
  • USP Monograph

How to read this page

We publish plain facts about this ingredient so a label is easier to read. This is not medical advice, and it is not a recommendation to buy, avoid, or use anything. For a personal health question, talk with a clinician who knows your history.

v1.0Updated 9/12/2026