Hydroxypropyl Methylcellulose

Thickeners & StabilizersCAS: 9004-65-3

This is what the ingredient is.

Hydroxypropyl methylcellulose (HPMC) is a semisynthetic polymer derived from cellulose, used in food and pharmaceutical applications.

Here is why it shows up on the label.

It works as a thickener, emulsifier, and film-former. Used in gluten-free baking, coatings, and plant-based foods.

Here is what food agencies say.

The FDA lists it as Generally Recognized as Safe. European food agencies allow it, with no ADI specified. It is widely approved around the world.

Here is what research has found.

an FAO/WHO expert committee reviewed safety data. Not absorbed by the body. Long history of safe use in foods and medications.

Here are a few things worth knowing.

Generally well-tolerated. Essentially non-toxic. May have mild laxative effect at high doses.

Sources

  • FDA CFR 21
  • EFSA Panel on Food Additives
  • JECFA

How to read this page

We publish plain facts about this ingredient so a label is easier to read. This is not medical advice, and it is not a recommendation to buy, avoid, or use anything. For a personal health question, talk with a clinician who knows your history.

v1.0Updated 9/12/2026