Disodium Inosinate

Flavor EnhancersCAS: 4691-65-0

This is what the ingredient is.

Disodium inosinate is the sodium salt of inosinic acid, a naturally occurring compound. Often derived from fish or produced through bacterial fermentation.

Here is why it shows up on the label.

Flavor enhancer that works synergistically with MSG to intensify umami taste. Used in processed foods, snacks, and instant noodles. Multiplies savory flavor when combined with glutamates.

Here is what food agencies say.

The FDA lists it as Generally Recognized as Safe. Europe has not set a numeric daily limit. It is approved in the US, Europe (as E631), and Canada.

Here is what research has found.

Safety reviewed by regulatory agencies. Generally well-tolerated. Works as nucleotide flavor enhancer. Limited safety concerns in scientific literature.

Here are a few things worth knowing.

May trigger gout attacks in susceptible individuals due to purine content. Should be used cautiously by those with hyperuricemia or gout. Generally safe for most people.

Sources

  • FDA 21 CFR 172.535
  • EFSA Opinion
  • JECFA Evaluation

How to read this page

We publish plain facts about this ingredient so a label is easier to read. This is not medical advice, and it is not a recommendation to buy, avoid, or use anything. For a personal health question, talk with a clinician who knows your history.

v1.0Updated 9/12/2026